Ascorbic acid in fetal human brain

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Ascorbic acid in fetal human brain.

Adlard, B. P. F., De Souza, S. W., and Moon, S. (1974). Archives of Disease in Childhood, 49, 278. Ascorbic acid in fetal human brain. Ascorbic acid concentrations in fetal human forebrain in the period 11 to 19 weeks' gestational age were 4 to 11 times higher than those of adults. Levels fell progressively with increasing gestational age but, in term babies dying within 4 weeks of birth, were ...

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Ascorbic acid (vitamin C) accumulation in activated human neutrophils is increased as much as 10-fold above the mM concentrations present in normal neutrophils. Internal concentrations as high as 14 mM are achieved when external vitamin is at physiologic concentration. The mechanism is by oxidation of external vitamin to dehydroascorbic acid, preferential transmembrane translocation of dehydroa...

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Ascorbic Acid Deficiency in Cultured Human Fibroblasts

Fibroblasts grown in medium containing less than 1 microg of ascorbic acid per milliliter showed evidence of ascorbic acid deficiency when compared with cells grown in medium containing 50 microg of ascorbic acid per milliliter. This was manifested morphologically by dilated endoplasmic reticulum, a decrease in number, size, and intensity of staining of the mitochondria, by defective intercellu...

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Biosynthesis of Ascorbic Acid in Human Beings

Introduction.?It is generally recognized that human beings, monkeys and guinea-pigs do not synthesize vitamin C in their body. The difference in the time of onset of the symptoms ?f vitamin C deficiency were attributed to differences in age, sex and locality. The great extent to which pregnant women could tolerate vitamin C deficiency could not be explained. It has, however, been suggested that...

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Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, in the connectional architecture of the human brain. Whether these hubs emerge in utero, has yet to be examined. The current study addresses this question and aims to determine the location of neural hubs in human fetuses. Fetal resting-state fMRI data (N = 105) was used to construct conne...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1974

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.49.4.278